© 2001-2010 Center for Technology in Teaching and Learning, Rice University. MedMyst is a problem-based adventure game provided in two versions. The original version engages the player in the role of a scientist/historian/detective who discovers infectious agents and transmission pathways. In the new reloaded version, students choose to work as an epidemiologist, microbiologist, or veterinarian to solve mysteries. Teacher materials and activities are provided. Available in Spanish.